Fig. 2: SMARCF subunits are found in all eukaryotes. | Communications Biology

Fig. 2: SMARCF subunits are found in all eukaryotes.

From: Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components

Fig. 2

a Domain architecture of known SMARCF subunits in H. sapiens, S. cerevisiae, C. subellipsoidea, and A. thaliana. Scale bar, 100 amino acids. b Graphical summary of the evolution of SMARCF domain architectures as predicted from Supplementary Fig. 1. The scale bar indicates the primary sequence length. Phylogram represents the suggested relationship between SMARCF subunits. Arrow indicates the duplication of a single SMARCF into SMARCF1 and SMARCF2 in a fungal and animal common ancestor. Domains are predicted based on Pfam and InterProScan hits, and depicted as colored boxes as indicated in the figure. ARM fold represents a series of ARM-fold hits (IPR016024 and IPR00025) and BAF250_C (PF12031/IPR033388); ARID, AT-rich interaction domain (PF01388/IPR001606); RFX DBD, RFX DNA-binding domain (PF02257/IPR003150); C2H2 Zf, zinc finger, C2H2 type (PF00096). H.s. Homo sapiens, S.c. Saccharomyces cerevisiae, R. irregularis Rhizophagus irregularis, C.s. Coccomyxa subellipsoidea, A. castellanii Acanthamoeba castellanii*, A.t. Arabidopsis thaliana, C. braunii Chara braunii. *A. castellanii (Amoebozoa), is a close relative of D. discoideum with a bona fide SMARCF subunit.

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