Fig. 5: FGF10 is essential for the differentiation of basal cells.
From: Cell response analysis in SARS-CoV-2 infected bronchial organoids
a BO-ALI were infected with SARS-CoV-2 (1.3 × 105 TCID50/well) and then cultured with a differentiation medium for 2 (a) or 15 (b) days. After the infection, BO-ALI were cultured with differentiation medium with or without FGF1, 2, or 10. The amount of infectious virus in the supernatant was measured by the TCID50 assay 2 days after the infection. Statistical significance was evaluated by one-way ANOVA followed by Dunnett’s post hoc test (*P < 0.05). Data represent the mean ± SD from three independent experiments. b Immunofluorescence analysis of acetylated α-tubulin (green) and KRT5 (red) 15 days after the infection. Nuclei were counterstained with DAPI (blue). Panel b is representative of three independent experiments.
