Fig. 2: Experimental paradigm with different brain states in the same environment. | Communications Biology

Fig. 2: Experimental paradigm with different brain states in the same environment.

From: The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states

Fig. 2

a We leveraged the power of an existing dataset from four non-human primates in different brain states (wake, sleep and four different forms of anaesthesia, see Methods for detailed description). The experimental paradigm consisted of two main manipulations of brain state measuring sleep and anaesthesia. For the sleep condition in the upper row, the non-human primate was awakened from sleep, leading to three sessions with sleep, awake with eyes closed and awake with eyes opened. For the anaesthesia conditions, the lower rows show the protocol with the injection of one of four pharmacological agents (propofol, medetomidine (MD), ketamine+MD and ketamine). The five sessions consisted of (1) awake eyes open, (2) awake eyes closed, (3) anaesthesia, (4) recovery eyes closed and (5) recovery eyes open. For the results reported here, only sessions with eyes closed were used. b The data from the sessions were recorded with electrocorticography (ECOG) from 128 electrodes covering one hemisphere in each of the non-human primates, with the combined locations shown in the subpanel and the locations in each individual shown in the other four subpanels.

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