Fig. 3: Schematic summarizing the spatial origins of retinal saccadic suppression.

Saccadic suppression in OFF RGCs (right) is mediated primarily by the central component of suppression (blue) that originates from the cells’ receptive field center. ON RGCs (left) get suppressed from two additional components: First, the fast but short-lived global component (red), mediated by GABAergic inhibition, that originates from as far as the cells’ periphery. This global component has a similar temporal profile as the central component. However, it is weaker than the central component and acts in parallel to it, indicated by the red arrows parallel to blue arrows in the total suppression schematic. Second, the delayed but long-lasting surround component (green), which might originate from the cell’s immediate surround. The central component and surround component do not depend on classical GABAergic or glycinergic inhibitory pathways. The differences in the suppression recovery time in ON and OFF RGCs was mainly due to this surround component acting on ON RGCs. Inset shows the legend for arrow schematics. Length of the arrows represent suppression strength; spread of the arrows show the temporal profile of suppression.