Fig. 3: Polyamine metabolism is linked to TCA cycle metabolism.

a Illustration of the TCA cycle indicating the metabolites and enzymes measured. b TCA cycle enzyme mRNA measured by Q-PCR and (c) TCA cycle metabolites measured by LC-MS following DFMO-mediated polyamine depletion in PHTs. Bar graphs show mean ± SEM, N = 8–10 male PHTs and N = 8–10 female PHTs.