Fig. 4: Suppression of cellular energy metabolism by polyamine depletion. | Communications Biology

Fig. 4: Suppression of cellular energy metabolism by polyamine depletion.

From: Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Fig. 4

Polyamine depletion by DFMO decreases (a) OXPHOS and (b) glycolysis in male PHTs. Inhibition of spermine synthesis by SMS-silencing decreases (c) OXPHOS and (d) glycolysis in both male and female PHTs. Induction of SSAT-mediated polyamine catabolism by DENSPM decreases (e) OXPHOS and (f) glycolysis in both male and female PHTs. Bar graphs show mean ± SEM, N = 8–10 male PHTs and N = 8–10 female PHTs. OCR oxygen consumption rate; ECAR extracellular acidification rate; were measured on a Seahorse bioanalyzer.

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