Fig. 5: Cell–cell interaction for vasculature development.
From: Remodeling of gene regulatory networks underlying thermogenic stimuli-induced adipose beiging
a UMAP plot of adipocyte progenitor and vascular endothelial and smooth muscle cells (n = 1,861). b Heatmap of normalized gene accessibility for cell-type markers. c GO analysis using the top 100 differentially accessible genes for each cell type. d Circle plot displaying VEGF signaling network inferred by gene accessibility of ligand-receptor pairs. Circle sizes are proportional to the size of each group. The circle and line colors represent the senders. The arrows indicate the receivers that receive signal from the corresponding senders. Thicker line indicates a stronger signal interaction. e Major contributors of ligand-receptor pairs of VEGF signaling network among the senders and the receiver. APC1 Adipocyte progenitor cell 1, APC2 Adipocyte progenitor cell 2, VEC Vascular endothelial cell, VSMC Vascular smooth muscle cell.
