Fig. 3: A joint predictor improves risk stratification for myocardial infarction in the UK Biobank.
From: Capturing additional genetic risk from family history for improved polygenic risk prediction
a Incorporation of parental disease history leads to calibration of polygenic risk scores. Individuals with a parental disease history are more likely to be considered at risk. The joint predictor achieves higher b area under the receiver operating characteristic curve (AUROC) and c area under the precision-recall curve (AUPRC), compared to the polygenic risk score and the parental disease history. d Performance of a data-driven joint predictor obtained from multivariate logistic regression is sensitive to sample size when using individual-level data. Boxplots represent distributions of AUROC obtained in 100 replicates corresponding to different sample sizes. AUROC of the joint predictor, polygenic risk score, and parental disease history are indicated by red, green, and blue dashed lines, respectively.
