Fig. 8: Bone remodeling markers in 3-week and 32-week-old Nox4fl/fl control, PrxCre+/- Nox4fl/fl CKO, and Nox4-/- mice.
From: Nox4 expression in osteo-progenitors controls bone development in mice during early life
Bone remodeling markers in serum were determined. a Serum ALP (bone-specific alkaline phosphatase) levels in 3 weeks (wks) old mice. b Serum ALP levels in 32 wks old mice. c Serum P1NP levels in 3 wks old mice. d Serum P1NP levels in 32 wks old mice. e Serum CTX1 levels in 3 wks old mice. f Serum CTX1 levels in 32 wks old mice. g Serum Cathepsin K levels in 3 wks old mice. h Serum Cathepsin K levels in 32 wks old mice. Data are expressed as mean ± SD, analyzed by one-way ANOVA, additionally, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by Tukey’s multiple comparison.
