Fig. 3: Sub-networks of the PPI network constructed with the functional protein association retrieved from the STRING database using the TWAS genes and meta-signatures.
From: Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning
The PPI network of the sub-network clustered using MCODE that were a cluster 1, b cluster 2, and c cluster 3. The size of each node is proportional to the degree of the node. The weight of each node (Z (TWAS) or meta-analysis log2FC) is indicated by the color of the node. The shape of the node indicates where the gene came from. A circle, rectangle, or triangle corresponds to genes involved in TWAS, meta-analysis, and the STRING database, respectively. Significantly associated genes in both TWAS and meta-analysis are marked with a red asterisk.
