Fig. 4: Identification of potential drugs for AD through in silico drug repositioning.

a A scatter plot of the calculated product score. Highly enriched drugs (product score > 0.6) are marked with red and annotated. b A scatter plot showing the correlation between the enrichment of perturbagens calculated with TWAS genes and meta-signatures. c The structure similarity analysis results comparing the potential drug candidates and reference drugs. The intensities of red rhombi are proportional to the cosine coefficient similarity index. d A network showing the similarities in MOAs of potential drug candidates and reference drugs. Red and blue nodes correspond to the potential drug candidates and reference drugs, respectively.