Fig. 8: Conditional deletion of Lkb1 in tyrosine hydroxylase expressing cells markedly slows the hypercapnic ventilatory response.
From: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response
Dot plots show mean ± SEM for increases in minute ventilation at ~30 s, 100 s and 300 s during exposures to a hypercapnic hypoxia (5% CO2 + 8%O2) and b hypercapnia (5% CO2) for TH-Cre (black; 8% O2 + 5% CO2, n = 17 independent experiments; 5% CO2, n = 20 independent experiments), conditional Lkb1 homozygous knockout mice (Lkb1 hom KO, red; 8% O2 + 5% CO2, n = 15 independent experiments; 5% CO2, n = 20 independent experiments), AMPKα1 + α2 homozygous floxed mice (AMPKα1 + α2 hom Fx, beige; O2 + 5% CO2, n = 20 independent experiments; 5% CO2, n = 20 independent experiments) and AMPKα1 + α2 homozygous knockout mice (AMPKα1 + α2 hom KO, purple, O2 + 5% CO2, n = 22 independent experiments; 5% CO2, n = 23 independent experiments). *=p < 0.05, **=p < 0.01.
