Fig. 2: Ig dynamics and anatomical distributions during SIVagm and SIVmac infections in the intestine.
From: NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections
a–c Longitudinal evaluation of IgA levels in the intestine. The ratio of the IgA signal per nucleus signal was measured by microscopy in a jejunum, b ileum, and c colon in non-infected (SIVneg) and SIV-infected at day 9 p.i. after infection (SIVacute) and chronic SIV infection (SIVchronic) in MAC (brown) and AGM (green). Three non-infected MAC (ileum, colon), five non-infected MAC (jejunum) and three non-infected AGM (jejunum, ileum, colon) were analyzed. Three MAC (jejunum, ileum, colon) and three AGM (jejunum, ileum, colon) were analyzed at day 9 p.i. Three chronic MAC (colon), four chronic MAC (ileum), five chronic MAC (jejunum), four chronic AGM (ileum) and three chronic AGM (jejunum, colon) were analyzed. A nonparametric Mann–Whitney test (p ≤ 0.05 = *; p ≤ 0.01 = **; p ≤ 0.001 = ***) was used. d Enlargements of the immunofluorescence staining of IgA (yellow) and nucleus (blue) in the colon from chronically SIVmac-infected MAC and chronically SIVagm-infected AGM (three chronic MAC and three chronic AGM). Arrows represent IgA+ cells and circles delineate the lumen zone. The images show a representative section in the ileum for one MAC and one AGM.
