Fig. 1: Structures of previously published G-G and G-A DNA cross-linking agents.
From: DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies
(1) The DNA G-G cross-linking PBD dimer SG3199, the ADC-payload component of Tesirine. (2) The A–A cross-linking agent Bizelesin, a cyclopropapyrroloindole (CPI) dimer shown in its bis-chloromethyl seco (prodrug) form. The three published families of CXI-PBD dimers capable of cross-linking Guanine and Adenine DNA bases: The Hurley et al. (3)11, Tercel et al. (4)12 and Lee et al. (5)13 hybrid dimers.
