Table 1 IC50 values for FGX8-46 (6) across a panel of 11 human cancer cell lines after 72 h incubation using an MTS assay (see Methods section).
From: DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies
Cell Line | Cancer Type | IC50 (nM) | SD |
|---|---|---|---|
SK-BR-3 | Breast | 0.055 | 0.006 |
MCF-7 | Breast | 2.72 | 0.484 |
ZR 75-1 | Breast | 0.486 | 0.080 |
U138-MG | Brain | 0.434 | 0.076 |
Reh | Lymphoblast | 0.0011 | 0.0001 |
SW48 | Colon | 0.022 | 0.003 |
SW620 | Colon | 0.069 | 0.007 |
LIM1215 | Colon | 1.30 | 0.400 |
RAJI, B | Lymphoblast | 0.073 | 0.024 |
JVM2 | Lymphoblast | 0.022 | 0.003 |
JURKAT | Lymphocyte | 0.047 | 0.012 |
