Fig. 1: Expression analysis of praja2 in glioma tissues. | Communications Biology

Fig. 1: Expression analysis of praja2 in glioma tissues.

From: Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Fig. 1

a Tissue sections from human astrocytoma grade II and GBM lesions were immunostained with anti-praja2 antibody and analyzed by stereological microscope. The images are representative of praja2 staining in low-grade (astrocytoma II) and high-grade (GBM) gliomas. IDH1 gene mutation status in tumor lesions is indicated. Images were acquired at 100X magnifications. Scale bar = 50 μm. b Graph represents the levels of praja2 in different histological types of glioma and are expressed as the density of positive cells for microscope fields. P value: ** = 0.002; ** = 0.007; *** = 0.00015. The IHC analysis was carried out on a total of 20 gliomas (ten with wild-type IDH1 and ten gliomas with IDH1-R132 mutation).

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