Fig. 9: Schematic diagram depicting the proposed signaling mechanisms underlying the effects of lncCIRPIL in the setting of I/R.
From: Cytoplasmic sequestration of p53 by lncRNA-CIRPILalleviates myocardial ischemia/reperfusion injury
Upon ischemia/reperfusion stress, the level of lncCIRPIL is decreased and p53 is increased in cardiomyocytes. The reduction of lncCIRPIL sequesters less p53 for ubiquitination mediated degradation. Thereby, more p53 translocate to nucleus to trigger the transcription of target genes to initiate cell apoptosis.
