Table 1 The effects of selected drugs on protein E and protein 3a from SARS-CoV-1 and -2, and ORF7b and ORF10 from SARS-CoV-2.
From: Reply to: How Many SARS-CoV-2 “Viroporins” Are Really Ion Channels?
SARS-CoV-1 | SARS-CoV-2 | |||||
|---|---|---|---|---|---|---|
Protein E % inhibition | Protein 3a % inhibition | Protein E % inhibition | Protein 3a % inhibition | ORF7b % inhibition | ORF10 % inhibition | |
Amantadine | 66 | ND | 77 | No effect | No effect | 61 |
Rimantadine | 37 | ND | No effect | No effect | No effect | No effect |
Adamantane | 50 | ND | No effect | No effect | No effect | No effect |
Xanthene | ND | ND | 80 | 20 | 75 | No effect |
Emodin | 32 | 26 | 60 | No effect | No effect | No effect |
Pyronin B | ND | ND | No effect | No effect | No effect | No effect |
Pyronin Y | ND | ND | No effect | No effect | No effect | No effect |
HMA | 68 | ND | 58 | ND | ND | ND |
