Fig. 5: ScRNAseq UMAP plots of IAV or SARS-CoV-2 infected lung ALI tissues. | Communications Biology

Fig. 5: ScRNAseq UMAP plots of IAV or SARS-CoV-2 infected lung ALI tissues.

From: Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents

Fig. 5

Tracheobronchial and alveolar ALI tissues were infected with PR8 IAV (1e5 TCID50 units/tissue, n = 2) for 48 h or SARS-CoV-2 (2e5 PFU/tissue, n = 2) for 72 h prior to dissociation for scRNAseq. Shown here are UMAP plots of: (a) Tracheobronchial tissues infected with mock media or PR8 IAV for 48 h (top, green), or with mock media or SARS-CoV-2 for 72 h (bottom, purple). b Alveolar tissues infected with mock media or PR8 IAV for 48 h (top, green), or with mock media or SARS-CoV-2 for 72 h (bottom, purple). Venn diagrams showing viral and tissue unique or shared genes with Log2FC values (c) >0.264 or (d) <-0.264 over mock in IAV or SARS-CoV-2 infected airway and alveolar tissues.

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