Fig. 6: Reward-sensitivity in dlPFC correlates with successful SN/VTA self-regulation. | Communications Biology

Fig. 6: Reward-sensitivity in dlPFC correlates with successful SN/VTA self-regulation.

From: Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain

Fig. 6

a Degree of successful SN/VTA transfer (midbrain DRT) in the neurofeedback task correlated with prefrontal reward sensitivity and adaptive coding in the MID task. A conjunction analysis around the peak coordinate in dlPFC showing midbrain DRT-related decreases in temporal difference coding during neurofeedback training (MNI x = 40, y = 10, z = 38, left) revealed common neural activity for non-midbrain DRT and general reward sensitivity (small + large reward magnitude parametric modulators in MID, all contrasts with p < 0.001 uncorrected). Moreover, individuals with more successful self-regulation of the SN/VTA showed stronger adaptive reward coding (which reflects higher sensitivity to small relative to large rewards) in the same region that also showed midbrain DRT-related decreases in temporal difference coding during neurofeedback training (right). b The scatter plot depicts the correlation between adaptive reward coding activity in dlPFC and midbrain DRT. The plot is for illustration purposes only without further significance testing to avoid double dipping. The grey shaded area identifies the 95% confidence interval (n = 25 subjects). See Supplementary Table 6 for full result overview.

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