Fig. 5: Biological implication in mitochondrial toxicity of the cell painting features correlated to gene expression. | Communications Biology

Fig. 5: Biological implication in mitochondrial toxicity of the cell painting features correlated to gene expression.

From: Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection

Fig. 5

Computational significance and biological implication in mitochondrial toxicity of the Cell Painting features that are most positively or negatively correlated to Gene Expression descriptors particularly unfolded protein response and endoplasmic reticulum stress (RNA variance and cell area shape), T cell apoptotic processes (mitochondrial granularity and DNA fragmentation) and side of the membrane (RNA granularity and heterogeneity in mitochondria). Further details in Supplementary Data 3. The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.

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