Fig. 6: Biological implication of Cell Painting features in relation to mitochondrial toxicity. | Communications Biology

Fig. 6: Biological implication of Cell Painting features in relation to mitochondrial toxicity.

From: Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection

Fig. 6

Biological implication of mitochondrial toxicity translated from the computational image statistics of Cell Painting features. Features were mainly related to edge intensity of cells (possibly related to integrity of cell wall), radial distribution and intensity in mitochondria (related to mitochondrial death) and granularity features (related to cell death and amount of information contained in cellular images). Further details in Supplementary Data 4. AGP Actin Golgi Plasma membrane, DNA Deoxyribonucleic acid, ER endoplasmic reticulum, Mito Mitochondria, RNA Ribonucleic acid. The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.

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