Fig. 7: Biological implication of gene expression features in relation to mitochondrial toxicity. | Communications Biology

Fig. 7: Biological implication of gene expression features in relation to mitochondrial toxicity.

From: Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection

Fig. 7

Biological implication of mitochondrial toxicity translated from the Gene Expression features. Features causing mitochondrial toxicity mainly related to unfolded protein response (possibly related to ER stress) and plasma membrane (related to membrane depolarisation). Some effects of mitochondrial toxicity were also captured by Gene Expression features such as oogenesis and dendritic plasma membrane; both processes are heavily mitochondria dependent. Further details in Supplementary Data 5. The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.

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