Table 1 Aggregation kinetics.

From: C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone

Protein

tlag (h)a

k b

t1/2 (h)c

FL-α-syn

7.4 ± 0.4

0.65 ± 0.03

10.5 ± 0.3

CT-α-syn

2.1 ± 0.3

1.1 ± 0.1

4.0 ± 0.3

Y39E-α-syn

NDd

NDd

NDd

FL-α-syn +PDI

23 ± 2

0.28 ± 0.05

30 ± 3

CT-α-syn +PDI

4.0 ± 0.3

0.7 ± 0.1

6.9 ± 0.6

Y39E-α-syn+PDI

36 ± 2

0.21 ± 0.03

46 ± 1

  1. aLag time.
  2. bElongation rate constant.
  3. cHalf-time of aggregation.
  4. dPlateau was not reached.
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