Fig. 5: DARS-AS1 promotes tumor proliferation in vivo and correlates with poor prognosis. | Communications Biology

Fig. 5: DARS-AS1 promotes tumor proliferation in vivo and correlates with poor prognosis.

From: Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress

Fig. 5

a–d Effect of DARS-AS1-knockdown on colorectal tumorigenesis in nude mice. Growth curve (a), tumor size (b), weight (c) and tumor image (d) are shown. Error bars represent ±SEM. n = 10. ****p < 0.0001, by two-tailed Student’s t test. e Kaplan–Meier analyses of the correlations between DARS-AS1 expression level and overall survival of patients with UVM, KICH, KIRP, MESO, GBM, and LGG. High, patients in the top 50% of DARS-AS1 expression levels; low, patients in the bottom 50% of DARS-AS1 expression levels. p values were determined using a log rank test. f Proposed model of DARS-AS1 in regulating PACT-PKR pathway and tumor growth.

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