Fig. 4: Microglia morphology dynamics in the acute reaction phase.
From: Long-term microglial phase-specific dynamics during single vessel occlusion and recanalization
a Images showing microglial response to vessel occlusion. Yellow circle indicates occlusion site. White circles indicate five representative microglial dynamics. Scale bar, 50 μm. b Microglia processes facing occlusion site elongate, non-occlusion facing process retract. Images show morphology changes of five microglia from near to far from the occlusion site at different time points. Their location was as shown in a. Arrows indicate the direction and the time at which microglia processes facing the vessel occlusion site elongate. Scale bar, 20 μm. c T-index heatmap of five microglia shown in b. The values of T-index at different time points are displayed. d Quantification of T-index during 24 h in response to occlusion (n = 4 mice, ****P < 0.0001, one-way ANOVA followed by Tukey’s multiple comparison). Error bars, mean and SEM.
