Table 2 Summary of key cellular transport parameters of ABTs in the absence and presence of cognate Ag.

From: Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

 

Uptakea

Recyclinga

Relative effect of Ag binding

ABT

pH 6.0

pH 7.4

pH 6.0

pH 7.4

Uptake

Recycling

Residual

Transcytosis

Infliximab

1.5

1.1

1.2

0.5

8.4

9.3

12.8

4.2

Adalimumab

1.7

1.6

1.7

1.1

5.3

6.9

3.2

2.5

Etanercept

0.2

0.4

0.1

0.2

0.6

3.0

2.1

NA

Aflibercept

4.2

6.7

0.9

1.3

7.4

4.3

3.9

2.5

Bevacizumab

1.3

0.8

0.8

0.4

13.9

9.7

NA

2.3

  1. aCalculated as relative to anti-NIP IgG1 in the absence of competition, i.e., data shown in Fig. 7b, d.
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