Fig. 4: Infection of primary hepatocytes regulates the renin-angiotensin system.
From: The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
a Extracellular levels of ANG(1–7) secreted by human primary hepatocytes after infection with pseudotyped viral particles compared to controls, measured by ELISA (n = 5, one-way ANOVA). b, c Percentage of infected hACE2 (b) or human (c) primary hepatocytes after infection with pseudotyped viral particles or controls in the presence of different doses of A779, measured by flow cytometry (n = 3, one-way ANOVA). d Relative MitoSOX fluorescence (n = 3, one-way ANOVA) and e extracellular ATP concentration (n = 4, one-way ANOVA test) of the indicated groups. Error bars represent SEM and asterisks represent p values (*<0.05, **<0.01, and ***<0.001).
