Table 3 Up to top 20 comorbidities, top 20 comorbidity enriched MOA proteins (with respect to input), and top 20 pathways (ranked by p value since q values are the same) associated with the prediction CAD GWAS-driven LeMeDISCO results using the gene set from ref. 30.

From: LeMeDISCO is a computational method for large-scale prediction & molecular interpretation of disease comorbidity

Comorbidities

MOA proteins

Pathways

Disease

J-score

q value

Gene name

Score

Pathway

q value

p value

Renal artery disease

0.028

5.8 × 10−4

PEX10

0.24

RAB geranylgeranylation

0.16

4.6 × 10−3

Anuria

0.022

5.3 × 10−3

BEND6

0.23

Platelet activation, signaling and aggregation

0.16

7.7 × 10−3

Anterior uveitis

0.015

0.022

NEURL1

0.22

MET activates RAP1 and RAC1

0.16

0.017

   

CCM2

0.20

RHO GTPases activate KTN1

0.16

0.017

   

FGD6

0.20

Response to elevated platelet cytosolic Ca2+

0.16

0.019

   

CENPW

0.20

Killing mechanisms

0.16

0.019

   

PCID2

0.20

WNT5:FZD7-mediated leishmania damping

0.16

0.019

   

RPL17

0.19

Diseases of signal transduction by growth factor receptors and second messengers

0.16

0.022

   

MANEAL

0.18

PTK6 Regulates RHO GTPases, RAS GTPase, and MAP kinases

0.16

0.022

   

HHAT

0.17

TFAP2 (AP-2) family regulates the transcription of growth factors and their receptors

0.16

0.024

   

PHYHIP

0.16

Purine catabolism

0.16

0.030

   

IYD

0.16

RHO GTPases activate CIT

0.16

0.031

   

VEGFA

0.16

Signal transduction by L1

0.16

0.033

   

HNRNPD

0.14

VEGFR2 mediated cell proliferation

0.16

0.033

   

AGT

0.13

RHO GTPases Activate NADPH Oxidases

0.16

0.037

   

PLEKHA1

0.12

RHO GTPases activate PAKs

0.16

0.037

   

SERPINA1

0.11

TRAF6 mediated NF-kB activation

0.16

0.037

   

NUDT5

0.04

Neutrophil degranulation

0.16

0.038

   

RAB23

0.04

NOTCH3 Activation and Transmission of Signal to the Nucleus

0.16

0.039

   

NKIRAS2

0.04

Signaling by NTRK2 (TRKB)

0.16

0.039

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