Fig. 3: The motor-centric approach yields convulsion-inducing nementin-1. | Communications Biology

Fig. 3: The motor-centric approach yields convulsion-inducing nementin-1.

From: Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

Fig. 3

a Structures of the seven prioritized neuromodulators. b Bioactivity of the seven prioritized molecules. Data are EC50s (details of assays are provided in the methods) except for the A. thaliana greening assay, which is the lowest concentration that yields a discernible difference from control in at least two of the three biological replicates tested (n = 3). c A time-course analysis of 60 µM nementin-1-induced locomotory phenotypes. Data are the mean of biological triplicate measurement of 18 animals per each time point over three biologically independent replicates (n = 3). The SEM is shown. Primary data for this figure can be found in Supplementary Data 2.

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