Fig. 1: L-DOPA treatment alters locomotor parameters of Drosophila. | Communications Biology

Fig. 1: L-DOPA treatment alters locomotor parameters of Drosophila.

From: Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses

Fig. 1

a Experimental scheme to analyze single fly trajectories upon L-DOPA diet using a fly movement tracking system. b, c Representative trajectories of flies on control and L-DOPA diet with indicated concentrations (b), and flies on D-DOPA vs L-DOPA diet (c). d Schematic illustrations to define speed, yawing and freezing as locomotor parameters. e Representative trajectories illustrating speed, yawing, and freezing extracted from 20 frames of movement videos of a control and an L-DOPA-fed fly. One frame corresponds to 0.033 seconds. Bars indicate 1 mm. f–h Comparisons of the quantified speed (f), fraction of freezing (g), and yawing (h) of the flies on L-DOPA diet with indicated concentrations. N = 6. ****p < 0.0001; **p < 0.01; *p < 0.05 by one-way ANOVA Tukey’s multiple comparison test. Data are presented as means ± SEM. p < 0.05 was considered statistically significant.

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