Fig. 4: Dop1R1 is necessary and sufficient for LID-like phenotypes. | Communications Biology

Fig. 4: Dop1R1 is necessary and sufficient for LID-like phenotypes.

From: Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses

Fig. 4

a Representative trajectories of the flies with indicated genotypes on a control, acute L-DOPA, and chronic L-DOPA diet. b, c Comparisons of the quantified speed (b), and AIM scores (c) of the flies with indicated genotypes. N = 6. ****p < 0.0001; **p < 0.01; n.s., not significant (p > 0.05) by two-way ANOVA Tukey’s multiple comparison test and are presented as means ± SEM. p < 0.05 was considered statistically significant. d Representative trajectories of the flies with indicated genotypes. e, f Comparisons of the quantified speed (e) and AIM scores (f) of the flies with indicated genotypes. N = 6. ****p < 0.0001; **p < 0.01; n.s., not significant (p > 0.05) by two-way ANOVA Tukey’s multiple comparison test. Data are presented as means ± SEM. p < 0.05 was considered statistically significant.

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