Fig. 6: dADCY2 functions downstream of Dop1R1 for LID-related phenotypes. | Communications Biology

Fig. 6: dADCY2 functions downstream of Dop1R1 for LID-related phenotypes.

From: Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses

Fig. 6

a, b Comparisons of the quantified speed (a) and AIM scores (b) of the flies in which twenty-three LID-related genes were pan-neuronally knocked down by RNAi expression driven by nSyb-GAL4. + denotes the flies bearing a copy of nSyb-GAL4 driver with no RNAi expression. D1 indicates the flies expressing Dop1R1 RNAi driven by nSyb-GAL4. Red boxes indicate Drosophila ADCY2 RNAi driven by nSyb-GAL4. Black (control) and white bars (L-DOPA) indicate control and L-DOPA diet. The mean speed and AIM score are depicted in red line. N = 6. c Representative trajectories of the flies with indicated genotypes upon control and L-DOPA diet. d, e Comparisons of the quantified speed (d) and AIM scores (e) of the flies with indicated genotypes. N = 6. ****p < 0.0001; n.s., not significant (p > 0.05) by two-way ANOVA Tukey’s multiple comparison test. Data are presented as means ± SEM. p < 0.05 was considered statistically significant.

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