Fig. 7: Phenotypical classification of the fly ADCY family reveals four distinct groups. | Communications Biology

Fig. 7: Phenotypical classification of the fly ADCY family reveals four distinct groups.

From: Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses

Fig. 7

a Representative trajectories of the flies with indicated genotypes upon control, acute and chronic L-DOPA diet. b, c Comparisons of the quantified speed (b) and AIM score (c) of the flies with indicated genotypes upon control, acute, and chronic L-DOPA diet. N = 6. ****p < 0.0001; ***p < 0.001; n.s., not significant (p >  0.05) by two-way ANOVA Tukey’s multiple comparison test. Data are presented as means ± SEM. p < 0.05 was considered statistically significant. d, e Heatmaps of quantified speeds and AIM scores in the flies with pan-neuronal knockdown of the four ADCY groups upon normal diet (control), acute and chronic L-DOPA diet. Blues indicate decrease and reds indicate increase of the log2 fold change. f A decision tree to illustrate the selection criteria for the ADCY groups.

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