Fig. 3: Therapeutic efficacy of intravenous cellular administration combined with intramuscular cellular delivery. | Communications Biology

Fig. 3: Therapeutic efficacy of intravenous cellular administration combined with intramuscular cellular delivery.

From: Repeated intravenous administration of hiPSC-MSCs enhance the efficacy of cell-based therapy in tissue regeneration

Fig. 3

Laser Doppler imaging analysis was performed immediately and every week following femoral artery ligation to evaluate blood perfusion in the ischemic hind limbs (a). After intramuscular transplantation of hiPSC-MSCs, blood perfusion was significantly improved in the MSC-Saline, MSC-MSC/once, MSC-MSC/week and MSC-MSC/3 days groups compared with the ischemia group from day 14 onwards (all p < 0.05). A single and repeated intravenous hiPSC-MSC infusion further improved blood perfusion in the MSC-MSC/once, MSC-MSC/week and MSC-MSC/3 days groups compared with MSC-Saline group (all p < 0.05). Moreover, the blood perfusion was significantly higher in the MSC-MSC/week and MSC-MSC/3 days groups compared with the MSC-MSC/once group (all p < 0.05). There was no significant difference between the MSC-MSC/week and MSC-MSC/3 days groups (p > 0.05) (b).

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