Fig. 5: Repeated intravenous administration of hiPSC-MSCs prolonged the survival of transplanted hiPSC-MSCs. | Communications Biology

Fig. 5: Repeated intravenous administration of hiPSC-MSCs prolonged the survival of transplanted hiPSC-MSCs.

From: Repeated intravenous administration of hiPSC-MSCs enhance the efficacy of cell-based therapy in tissue regeneration

Fig. 5

A series of fluorescent images of ischemic hind limbs was performed immediately and every week following intramuscular transplantation of hiPSC-MSCs to detect the fate of intramuscularly transplanted hiPSC-MSCs (a). A single or repeated intravenous hiPSC-MSCs infusion in the MSC-MSC/once, MSC-MSC/week and MSC-MSC/3 days groups significantly prolonged the survival of intramuscular transplanted hiPSC-MSCs from day 14 onwards compared with the MSC-Saline group (all p < 0.05). Moreover, repeated intravenous hiPSC-MSCs infusion in the MSC-MSC/week and MSC-MSC/3 days groups further improved the survival of intramuscularly transplanted hiPSC-MSCs from day 21 onwards compared with the MSC-MSC/once group (all p < 0.05), whereas no significant difference was observed between MSC-MSC/week and MSC-MSC/3 days groups (p > 0.05) (b).

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