Fig. 3: Comparison of cocaine-induced tissue oxygenated-hemoglobin (HbO2) changes between Group N (neuronal) and Group A (astrocytic) mice.
From: Cocaine’s cerebrovascular vasoconstriction is associated with astrocytic Ca2+ increase in mice
a, b Time lapse Δ[HbO2] images in response to cocaine (1 mg/kg, i.v) in a Group N animal (ii–v) and a Group A animal (ii–v) at t = 0, 5, 25, 40 min, respectively. Three ROIs were selected in tissue (e.g., yellow dots) from each animal. c Mean Δ[HbO2] changes with time in response to cocaine (1 mg/kg, i.v) in Group N (solid line, n = 5) and Group A (dashed line, n = 5), showing cocaine-induced Δ[HbO2] decrease in cortical tissue over 20–25 min followed by an overshoot over baseline about 10–15% at t = 60 min after cocaine. d Comparison of peak Δ[HbO2] decreases between G(N) and G(A), showing no difference (n = 5, p = 0.584). e Comparison of Δ[HbO2] return time to baseline between G(N) and G(A), showing no difference (n = 5, p = 0.909). All error bars are presented as means ± SEM.
