Fig. 5: OT induced differential gene expression in GABA-ergic neurons of the dorsal horn.
From: Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats
Heat map of the altered genes in the laminae I–II (a) and laminae III–VI (b) of the spinal cord after the chemogenetic activation of endogenous OT by using RNAseq. The samples for the analysis were collected at 120 min after the s.c. injection of Saline or CNO (1 mg kg−1). Scale represents normalized values subtracted by row mean divided by standard deviation. Volcano plot of the genes in the laminae I–II (c) and laminae III–VI (d) of the spinal cord. The genes that were significantly altered were depicted by orange color dots. Red-colored dots indicate subset of the genes that are predominantly expressed in GABA-ergic neurons. Gene ontology (GO) terms that were enriched by endogenous OT in the laminae I–II (e) and laminae III–VI (f) of the spinal cord. Raw RNA sequencing data are available at Gene Expression Omnibus (GEO) in the National Center for Biotechnology Information (NCBI) (accession number GSE210528). See also Supplementary Figs. 5, 6.
