Fig. 1: TEX12 is a synaptonemal complex and centrosomal protein.
From: Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip
a TEX12 has known cellular roles in meiotic chromosome synapsis and centrosome function. An SYCE2-TEX12 complex assembles into fibres to provide the backbone of the synaptonemal complex (SC) that mediates meiotic chromosome synapsis14. TEX12 also undergoes SYCE2-independent recruitment to centrosomes during meiosis, and in cancer cells where it contributes to centrosome dysfunction9. b In the SC, TEX12’s Ctip drives hierarchical assembly of SYCE2-TEX12 from a 2:2 complex to a 4:4 complex (blocked by TEX12 ΔCtip and LFIL mutations), and into ‘intermediate filament’-like fibres (blocked by TEX12 FFV mutation)14. c Schematic of the human TEX12 sequence in which its structural core (amino-acids 49–123) and Ctip (amino-acids 114–123) are highlighted, alongside a sequence alignment of TEX12’s C-terminus indicating heptad predictions and amino-acids mutated in this study (modified from ref. 14).
