Fig. 1: Cancer patients with T2D treated with radiotherapy (RT) may present stronger metabolic impairment effects than those not treated with RT. | Communications Biology

Fig. 1: Cancer patients with T2D treated with radiotherapy (RT) may present stronger metabolic impairment effects than those not treated with RT.

From: Low-dose radiation exaggerates HFD-induced metabolic dysfunction by gut microbiota through PA-PYCR1 axis

Fig. 1

a Correlation analyses of radiotherapy-related genes using the online cBioPortal database (http://cbioportal.org), a resource for exploration, visualization, and analysis of complex cancer genomics and clinical profile data from TCGA. b Timeline for the mice subjected to HFD, LDR (0.05 Gy*10) or LDR (0.05 Gy*10) + HFD. c Blood glucose levels at the indicated time points among the Con, LDR, HFD and LDR + HFD groups. d HOMA-IR values at the indicated time points among the Con, LDR, HFD and LDR + HFD groups. e Mice were administered an antibiotic cocktail (50 g/L penicillin G sodium, 50 mg/L metronidazole, 100 U/L streptomycin, and 0.4 g/L neomycin sulfate) in their drinking water for 14 days, after which the mice were subjected to LDR, HFD or LDR + HFD treatment. The mice were killed at 14 weeks, and the HOMA-IR values were detected. The data are the means ± standard deviations (SDs). The Mann-Whitney test or two-tailed unpaired Student’s t-test was used for statistical analyses. *p < 0.05 indicates a significant difference. Error bars indicate SEM (standard error of the mean). b was created by Ruixue Huang.

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