Fig. 3: Elevation of scIgGs in tumor tissues promoted cancer cell metastasis and poor survival in mouse tumor models.
From: Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions
a The scIgG containing 4T1-IdeS tumors had more micro-metastasis in lung tissues in comparison with that in wild type 4T1 (control) mice, n = 5 per group. A representative lung image (10x magnification) is shown for 4T1-IdeS and 4T1 (control) group and blue arrows indicate tumor micro-metastasis on lung tissues detected using a light microscope. A representative image of a tumor nodule (lower panel images) was taken with 800× magnification. b Average number of lung tumor micro-metastasis (tumor lung nodules/number of mouse) in 4T1-IdeS mouse tumor model was much higher than that in mice with 4T1 control tumor model, n = 5, p < 0.05. c Survival percentage (log-rank plot) of PyMT+/scIgG+ double transgenic mice was significantly lower than that for PyMT+ control mice, n = 22 per group, p < 0.05. Mouse survival time (days) was counted from the date with tumor initiation (palpable tumor) to the date when mice reached maximum tumor burden (>1000 mm3) for termination.
