Table 1 Statistically significant (P < 2 × 10−6) results from PheWAS of an aggregate of up to 110 pLOF and deleterious missense variants (MAF < 1%) in ANGPTL7 in UKB.
From: ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma
Trait | P value | OR/Effect in SD (LCI | UCI) |
|---|---|---|
Corneal-ompensated intraocular pressure (IOPcc) (mean of both eyes) | 6.32E–14 | −0.17 [−0.21 | −0.13] |
CRF (right eye) | 5.20E–13 | −0.16 [−0.20 | −0.11] |
CRF (left eye) | 4.50E–12 | −0.15 [−0.20 | −0.11] |
6 mm weak meridian (left eye) | 4.00E–20 | 0.21 [0.16 | 0.25] |
6 mm weak meridian (right eye) | 4.20E–18 | 0.19 [0.15 | 0.24] |
6 mm strong meridian (left eye) | 3.10E–17 | 0.19 [0.14 | 0.23] |
6 mm strong meridian (right eye) | 7.60E–17 | 0.18 [0.14 | 0.23] |
3 mm weak meridian (right eye) | 2.00E–14 | 0.16 [0.12 | 0.20] |
3 mm weak meridian (left eye) | 1.60E–13 | 0.15 [0.11 | 0.20] |
3 mm strong meridian (left eye) | 1.30E–12 | 0.15 [0.11 | 0.19] |
3 mm strong meridian (right eye) | 1.80E–12 | 0.15 [0.11 | 0.19] |
Corneal power (mean of both eyes) | 1.10E–13 | 0.16 [0.11 | 0.20] |
