Fig. 1: The deficient metabolic conversion of P5C to glutamic acid leads to aberrant reactivity. | Communications Biology

Fig. 1: The deficient metabolic conversion of P5C to glutamic acid leads to aberrant reactivity.

From: Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II

Fig. 1

a Deficiency of P5C dehydrogenase leads to the accumulation of P5C and glutamate 5-semialdehyde. b Reaction of P5C with PLP leads to the deactivation of the latter. c Previously proposed biomarkers for HPII6. d Biomarkers of P5C with 1,3-dicarbonyl compounds were identified in this study.

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