Fig. 3: Individuals with neuropathic pain had higher alpha power in the right ANP state and higher beta band power in the SMN state. | Communications Biology

Fig. 3: Individuals with neuropathic pain had higher alpha power in the right ANP state and higher beta band power in the SMN state.

From: A Hidden Markov Model reveals magnetoencephalography spectral frequency-specific abnormalities of brain state power and phase-coupling in neuropathic pain

Fig. 3

Brain nodes in neuropathic pain (NP) showing significant local power increased (red nodes) and decreased (blue nodes) in the a right Ascending nociceptive pathway (ANP: higher alpha power in the right thalamus, primary somatosensory (S1), and motor cortex (M1), posterior insula (pINS), temporo-parietal junction (TPJ) and lower power in the dorsolateral prefrontal cortex (DLPFC), medial prefrontal cortex (mPFC), and left anterior insula (aINS) and b sensorimotor (SMN: S1 and TPJ, but had lower power in frontal regions including the DLPFC, mPFC, dorso-medial prefrontal cortex (dmPFC), subgenual anterior cingulate cortex (sgACC), midcingulate cortex (MCC) and sensorimotor area (SMA) state compared with healthy controls (HCs) are depicted. The effect size (Cohen’s d) between the average power of n = 40 healthy controls and n = 40 individuals with neuropathic pain is shown in the Gardner-Altman estimation plots. 5000 bootstrap samples were taken; the confidence interval is bias-corrected and accelerated. Each dot on the brain maps represents a brain region, and its size is in relation to the difference in spectral power between the neuropathic pain and control groups (i.e., proportional to the effect size, larger dot means a stronger difference).

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