Fig. 4: Coherence changes in individuals with neuropathic pain compared to HC group in specific frequency ranges. | Communications Biology

Fig. 4: Coherence changes in individuals with neuropathic pain compared to HC group in specific frequency ranges.

From: A Hidden Markov Model reveals magnetoencephalography spectral frequency-specific abnormalities of brain state power and phase-coupling in neuropathic pain

Fig. 4

The brain maps show connections (in blue) associated with significant changes between neuropathic pain and healthy control groups in one brain state; each dot (black) represents one brain region. In the circular coherence plots, blue and red/yellow colors reflect respectively coherence that is lower and higher in neuropathic pain than in the control group. In neuropathic pain patients, we found that the coherence was a higher in the salience (SN; left: S1, pINS, aINS, thalamus, caudate, mPFC, MCC, sgACC; right: DLPFC, M1, medial temporal lobe (MTL), pINS, S1, posterior cingulate cortex (PCC), Precuneus, occipital lobe) state in the alpha band; and b in the sensorimotor (SMN; dmPFC, mPFC, sgACC, MTL, pallidum, putamen, caudate Left: occi, TPJ, S1, M1, DLPFC, right: amygdala, S2) state in the beta band, c whereas coherence was lower in the dorsal attention state (sgACC, MCC; right: aINS, DLPFC, pallidum, putamen) in the delta/theta compared with healthy control. *P < 0.01, corrected 5000 permutations, network-based statistic method.

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