Fig. 5: Brain states temporal features: chronnectome in healthy controls and disturbances associated with neuropathic pain. | Communications Biology

Fig. 5: Brain states temporal features: chronnectome in healthy controls and disturbances associated with neuropathic pain.

From: A Hidden Markov Model reveals magnetoencephalography spectral frequency-specific abnormalities of brain state power and phase-coupling in neuropathic pain

Fig. 5

a Distribution of state life times, b distribution of interval times between state visits, and c fractional occupancies (proportion of time spent in each state) are depicted for the n = 40 healthy controls group. The two states related to the default mode network (DMN) have distinct temporal features compared with the other states. The posterior DMN state had higher lifetimes, and both posterior and anterior DMN states had higher interval times, but the proportion of time spent in the posterior DMN state was lower compared to the other states (P < 0.01). In n = 40 participants with neuropathic pain, d the maximum fractional occupancy was lower, and e the sensorimotor (SMN) was more frequently active compared with n = 40 healthy controls. f The proportion of time spent was higher in the SMN state and lower in the dorsal attention state compared to healthy controls. Standard deviations are shown. *P < 0.01; permutation P value, 5000 bootstrap samples. DMN Default mode network, SMN sensorimotor, HC healthy control, NP neuropathic pain.

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