Fig. 5: MMV668754/Trifloxystrobin inhibited the transformed phenotype. | Communications Biology

Fig. 5: MMV668754/Trifloxystrobin inhibited the transformed phenotype.

From: Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance

Fig. 5

a Infected macrophages (TaC12) or infected B lymphocytes (TBL3) were treated with the designated drugs MMV688754, MMV688372 or Buparvaquone (Bup) for 48 h and key transformation associated genes were evaluated by qRT-PCR analysis compared to DMSO controls. The MMV668754/Trifloxystrobin and Bup treatment had equivalent inhibitory effects on bovine gene expression. Mean values ± SD, standardized using bovine actin expression. n = 3 independent experiments. One-way Anova statistical test, Dunnett’s multiple comparison test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. b Soft-agar analysis demonstrated that the drug treatment also affected the colony growth of TBL3 cells. The results shown are representative of two independent experiments.

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