Fig. 6: Sequence composition of TCR alpha and beta chains. | Communications Biology

Fig. 6: Sequence composition of TCR alpha and beta chains.

From: Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice

Fig. 6

a Length distributions of CDR3 regions. Note the peaks occurring at every third nucleotide position, representing in-frame sequences; CDR3 sequences of other sizes (indicative of out-of-frame sequences) make only minor contributions to the overall repertoire. The latter type is essentially lacking in sequences of the peripheral repertoire (spleen), as a result of efficient purging of non-functional rearrangements from the repertoire. b Clone sizes of TCR beta clonotypes. Note that the wild-type exhibits a larger number of clones that are associated with only a single UMI, indicative of a greater complexity of the repertoire.

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