Fig. 5: Anatomy-function correlation of Mela(CTmGluR6)-triggered RGC responses in the treated rd1 retina determined by patch-clamp. | Communications Biology

Fig. 5: Anatomy-function correlation of Mela(CTmGluR6)-triggered RGC responses in the treated rd1 retina determined by patch-clamp.

From: Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina

Fig. 5

Anatomy and corresponding light responses of 4 example RGCs from Mela(CTmGluR6)-treated rd1 retinas show that some native OFF RGCs (a, b) have inverted light responses (i.e., dendrites that stratify in the OFF sublamina of the inner plexiform layer (IPL) with a light response at the onset of light), while the light responses of other cells (c, d) are not inverted (i.e., cells that stratify in the OFF sublamina of the IPL respond at the end of the light stimulus). Also, see Supplementary Table 1. Light stimulus indicated as blue bar above spike trains (470 nm; 1014 photons/cm2/s). Scale bars = 100 µm.

Back to article page