Fig. 2: Genetic association between body mass index and childhood- and adult-onset asthma. | Communications Biology

Fig. 2: Genetic association between body mass index and childhood- and adult-onset asthma.

From: Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma

Fig. 2

a The circle Manhattan plot shows P-values of genome-wide association studies (GWAS) for body mass index (BMI) and childhood- and adult-onset asthma. From inner to outer circle: childhood BMI, adult BMI, childhood-onset asthma, and adult onset asthma. The circle Manhattan plot is customized to truncate the P-values at 1 × 10−40. b The genetic correlation coefficients for each pair of traits. The nominal significance level of genetic correlation (P < 0.05) is marked by one asterisk, and P < 0.01 is marked by two asterisks. c, d Genetic multivariable regression in genomic structural equation modeling evaluates the association between BMI and childhood- and adult-onset asthma. c The association between childhood BMI and childhood-onset asthma adjusting for the genetic effects of adult BMI. d The association between childhood BMI and adult onset asthma adjusting for the genetic effects of adult BMI.

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